We had a coworker who went on vaction for a couple of weeks.  While he was gone someone from Human Resources came down to make a presentation about working with people who were transitioning. This was how we found out that out 400-lb., bald, male coworker with a neon pink beard would be coming back from vacation in a few days as a female with a different name.

This was all new to me, but I figued I would do my best. I did pretty well, only calling her by her dead name a couple of times and only using "him" as opposed to "her" once or twice.  But she could see that I was making an effort and that her transition didn't really change anything as far as our work relationship (we even talked about thing like how ludicrous she might look in some fashion choices, and whether a wig might improve things - while still choosing to keep the beard). She remained working there, and everyone was pretty accepting of the new status quo, But she left about six months later to take a position at a library closer to her home.

Before she left though she gave me what I consider to be a nice, albeit backhanded, compliment.  She told me "I was pretty cool for a old cis white guy."  Which, while I took it like it was intended, I think it was also a pretty sad commentary about what transgenders expect the reaction by people my age would be.  Being raised Baptist it was certainly out of my comfort zone at the start, but I figured out pretty quickly that nothing had really changed except for her outward appearance.

I also have another former coworker from about 30 years ago that recently went in the other direction and now identifies as male.  Tht wasn't as awkward a situation for me to get accustomed to, mainly because I didn't see him at work every day anymore, but our correspondence has been pretty matter of fact about it.

However, reading some of the reactions to Isabella's transition is rather disheartening, I want to think we should be progressing as a society in regards to these types of choices, and we should respect the decisions they make, but there are still a lot of people who take her choice as a great offense to their values system and choose to react in a lot of petty and vindictive ways.  All this to someone they don't know who has never done anything to them.  But that is the atmosphere our "leadership" in the White House embraces.  Which to me is a huge indication thatthe orange turd is unfit for the office he holds.