Al Ewing seemingly took us to a future where Bruce mentally surrendered and a being call the The One Below All who can act through others used the Hulk and his limitless strength to break the cosmos.

I have always seen Bruce's core personality as a governor that holds his alter-ego aspect in check. Woe to everyone if he surrenders that responsibility or just as bad immerses himself in the rage as well.

*More likely, he'd "leap" the moon out of orbit.

"Hey, I got an idea! I'll make a character STRONGER THAN THE UNIVERSE IS DURABLE!"

That said, the Hulk's limitless strength is best left as a hypothetical notion rather than fully explored. Infinite anything doesn't really suit any story.

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See, I think it's specifically BECAUSE the Hulk has been around for decades that they went this route.  Each writer has to top the last writer.  Each story has to be "bigger."

If they created a new man-into-monster character, his power level would probably start off much lower.  "Ooh, he can break a padlock with his hand!  Ooh, he can punch through a wall with only one or two hits!  Ooh, he can actually lift a car off the ground--with only some strain!"

Superman went from lifting wife-beaters off the ground with one hand to pushing moons out of orbit.  And Marvel always tries to be like DC (for some reason).

The cover of issue #6 back at the beginning references his limitless strength and it follows into Tales to Astonish. Here are just a couple examples. It's what Stan and Jack established and I don't think you can fault a particular writer or artist in exploring that in their own ways. It works in the Hulk where it may not work with other characters or books because their is so much inner turmoil with the character. Limitless strength in the case of Bruce Banner can be just as much a limitless curse as a limitless blessing.

Give the story a chance before jumping to conclusions. Ewing has been solid so far and has respected and used the history of the characters. 

Other than tossing him into another universe or dimension and hoping he doesn't find his way back, total disintegration (maybe?) or tossing him into the sun......

And thus, another big question - could Kitty Pryde or the Vision destroy the Hulk? I can't imagine him regenerating his brain.

Drop him onto Jupiter. By the time he reaches its solid core, likely he'll have suffocated, or gotten stuck in the atmospheric pressure. Even if not, it'd be like trying to jump out of water to escape the thousands of miles of gas above him to open space.

Also, he admits he was influenced the by all previous artists but says the Lee, Ditko and Kirby's original six and the early days of the Hulk was key. He likens his run to the fact even those comic titans had a hard time pinning the character down and he was in flux for quite a while. In the Avengers he was a hero in the first couple books and a quasi enemy in the very next issue. He see Banner/Hulk as a creature of chaos and why he went with the monster/horror aspect in his run. IMHO it's been very good.